Robbie Rouse ran for 151 yards and two touchdowns for Fresno State (4-8, 3-4), which never got the ball back after pulling to within three points on a Derek Carr touchdown pass with 6:15 remaining.
Matt Faulkner passed for 363 yards and two second-half touchdowns as San Jose State edged Fresno State 27-24 on Saturday night.
Noel Grigsby caught eight passes for 114 yards and a touchdown for San Jose State (5-7, 3-4 Western Athletic Conference), which defeated Fresno State for just the second time in 19 meetings. It was also the Spartans' first victory at Bulldog Stadium since 1987.
Carr finished with 276 passing yards, including a 24-yard touchdown pass to Jalen Saunders.
San Jose State took over at its 31-yard line and marched 56 yards on 13 plays to run out the clock. The Spartans were aided by a pass-interference penalty.
Fresno State's only home victories in 2011 were against North Dakota State and Utah State. The last time the Bulldogs finished with a record below .500 at Bulldog Stadium was in 2008 (2-3).