After sitting for the last 16 minutes of the first half, Guerrero opened the second half with a 3-pointer to extend their 12 point halftime lead to 15 points. Not long after, Guerrero picked up his third foul and the Mustangs rallied back to cut the lead to five.
That's where Cal Poly's comeback would end, however.
Leading 40-35 with 14 minutes remaining, Fresno State held the Mustangs to just one made field goal in the next 13 minutes of the game as the Bulldogs outscored Cal Poly 23-6 and pushed their lead to 22 points.
Fresno State keyed in on Cal Poly's top two scorers, Chris Eversley and Kyle Odister. Eversley had 14 points, but Odister never got his shot going. The 3-point marksman made just 1-of-8 attempts from the field and finished with only 3 points.
"He's a key guy for them," Fresno State head coach Rodney Terry said of Odister. "He's a senior and he's a guy they rely on to make shots for them to kind of give them an outside threat. We did a great job of really taking away any open looks for him."
The Mustangs failed to get a single point from their bench and struggled to get anything going without their top offensive players performing well.
With Guerrero limited to 14 minutes, the Bulldogs got a solid game from Allen Huddleston off the bench. Huddleston led the Bulldogs with 14 points and 7 rebounds. Six different Bulldogs finished in double figures on the night.
Fresno State next plays at Pacific on Saturday. Tip-off is at 7:30pm PT.