Hector Hernandez had 12 points for Fresno State (6-5), and Tyson Parker added 11 points and six rebounds, as the Bulldogs held the Blue Hose to its lowest point total of the season.
Pierre Miller had 11 points for Presbyterian (1-13), which committed 22 turnovers in dropping its fifth straight road game.
Fresno State shot 49.0 percent from the field compared to 32.6 percent for the Blue Hose.
Eddie Miller finished 5-of-7 from 3-point range for the Bulldogs and collected five of his team's 15 steals.
Fresno State led the entire game except for a couple possessions early in the first half.
Presbyterian trimmed the deficit to 36-26 on Al'lonzo Coleman's layup with 16:56 remaining, but the Bulldogs answered with a 14-3 spurt to put the game away.
Coleman and Travis Sligh had nine points apiece for the Blue Hose.
Hernandez's 3-pointer with less than a second remaining sent Fresno State into the locker room with a 32-20 lead.
The Bulldogs closed the half on a 13-2 run that included consecutive Miller 3-pointers. Miller had 12 points in the first half, all coming from beyond the arc.
Fresno State led 9-2 early before going more than 7 minutes without a field goal, allowing Presbyterian to hang around.
The Blue Hose were playing the fifth game of an 11-game road trip, including three in California.